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| First Name: | Jose Maria | | Last Name: | Frade | | Title: | Dr | | Advanced Degrees: | PhD | | Affiliation: | Cajal Institute (CSIC) | | Department: | Molecular, Cellular and Developmental Neurobiology | | Street Address 1: | Avda. Doctor Arce, 37 | | City: | Madrid | | Zip/Postal Code: | E-28002 | Country/Territory: | Spain | | Phone: | +34-91-585-4740 | | Fax: | +34-91-585-4754 | | Email Address: |  |
Disclosure:
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Member reports no financial or other potential conflicts of interest. [Last Modified: 27 December 2010]
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View all comments by Jose Maria Frade
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1989 MS in Biology
1994 PhD
1995 Postdoctoral fellow (Cajal Institute)
1996-1998 Postdoctoral fello (MPI of Neurobiology)
1999- Research Scientist (Cajal Institute) |
Nikoletopoulou V, Lickert H, Frade JM, Rencurel C, Giallonardo P, Zhang L, Bibel M, Barde YA. (2010) Neurotrophin receptors TrkA and TrkC cause neuronal death whereas TrkB does not. Nature 467: 59-63. PMID: 20811452.
Frade JM, López-Sánchez N. (2010) A novel hypothesis for Alzheimer's disease based on
neuronal tetraploidy induced by p75(NTR). Cell Cycle 9: 1934-1941. PMID: 20436277.
Morillo SM, Escoll P, de la Hera A y Frade JM (2010) Somatic Tetraploidy in specific chick retinal ganglion cells induced by nerve growth factor. Proc. Natl. Acad. Sci. USA 107: 109-114. PMID: 20018664.
Cisneros E, Latasa MJ, García-Flores M, Frade JM. (2008) Instability of Notch1 and Delta1 mRNAs and reduced Notch activity in vertebrate neuroepithelial cells undergoing S-phase. Mol Cell Neurosci 37: 820-831. PMID: 18289870.
López-Sánchez N, González-Fernández Z, Niinobe M, Yoshikawa K, Frade JM (2007a) Single mage gene in the chicken genome encodes CMage, a protein with functional similarities to mammalian type II Mage proteins. Physiol. Genomics 30: 156-171. PMID: 17374844.
López-Sánchez N, Rodríguez JR, Frade JM (2007b) Mitochondrial c-Jun N-terminal kinase prevents the accumulation of reactive oxygen species and reduces necrotic damage in neural tumor cells that lack trophic support. Mol. Cancer Res. 5: 47-60. [Cover caption]. PMID: 17210797.
Frade JM (2005) Nuclear translocation of the p75 neurotrophin receptor cytoplasmic domain in response to neurotrophin binding. J. Neurosci. 25: 1407-1411. PMID: 15703394.
López-Sánchez N, Müller U, Frade JM (2005) Lengthening of G2/mitosis in cortical precursors from mice lacking β-amyloid precursor protein. Neurosci. 130: 51-60. PMID: 15561424.
Murciano A, Zamora J, López-Sánchez J, Frade JM. (2002) Interkinetic nuclear movement may provide spatial clues to the regulation of neurogenesis. Mol Cell Neurosci. 21: 285-300. PMID: 12401448.
Frade JM (2000) Unscheduled cell cycle re-entry induced by NGF precedes cell death in nascent retinal neurones. J. Cell Sci.113: 1139-1148. PMID: 10704365. |
to find out a comprehensive model integrating all known hallmarks of neurodegeneration |
Park et al. (2007) Conditional neuronal simian virus 40 T antigen expression induces Alzheimer-like Tau and Amyloid pathology in mice. J. Neurosci. 27: 2969-2978.
Mosch et al. (2007) Aneuploidy and DNA replication in the normal human brain and Alzheimer's disease. J Neurosci. 27: 6859-6867.
Iacono et al. (2009) The Nun study: clinically silent AD, neuronal hypertrophy, and linguistic skills in early life. Neurology. 73: 665-673.
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transgenic mice inducing cell cycle re-entry in basal forebrain colinergic neurons |
cell cycle re-entry in neurons induces neuronal malfunction leading to slow neurodegeneration |
functional studies in "cycling" neurons |
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